An experimental method for evaluating constitutive models of myocardium in in vivo hearts

L. L. Creswell, M. J. Moulton, S. G. Wyers, J. S. Pirolo, D. S. Fishman, W. H. Perman, K. W. Myers, R. L. Actis, M. W. Vannier, B. A. Szabo, M. K. Pasque

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A new experimental method for the evaluation of myocardial constitutive models combines magnetic resonance (MR) radiofrequency (RF) tissue-tagging techniques with iterative two-dimensional (2-D) nonlinear finite element (FE) analysis. For demonstration, a nonlinear isotropic constitutive model for passive diastolic expansion in the in vivo canine heart is evaluated. A 2-D early diastolic FE mesh was constructed with loading parameters for the ventricular chambers taken from mean early diastolic-to-late diastolic pressure changes measured during MR imaging. FE solution was performed for regional, intramyocardial ventricular wall strains using small-strain, small- displacement theory. Corresponding regional ventricular wall strains were computed independently using MR images that incorporated RF tissue tagging. Two unknown parameters were determined for an exponential strain energy function that maximized agreement between observed (from MR) and predicted (from FE analysis) regional wall strains. Extension of this methodology will provide a framework in which to evaluate the quality of myocardial constitutive models of arbitrary complexity on a regional basis.

Original languageEnglish (US)
Pages (from-to)H853-H863
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume267
Issue number2 36-2
DOIs
StatePublished - 1994

Keywords

  • finite element analysis
  • magnetic resonance imaging
  • ventricular wall strain

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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