An exploratory analysis of the impact of family functioning on treatment for depression in adolescents

Norah C. Feeny, Susan G. Silva, Mark A. Reinecke, Steven McNulty, Robert L. Findling, Paul Rohde, John F. Curry, Golda S. Ginsburg, Christopher J. Kratochvil, Sanjeev M. Pathak, Diane E. May, Betsy D. Kennard, Anne D. Simons, Karen C. Wells, Michele Robins, David Rosenberg, John S. March

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N=439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments.

Original languageEnglish (US)
Pages (from-to)814-825
Number of pages12
JournalJournal of Clinical Child and Adolescent Psychology
Issue number6
StatePublished - 2009

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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