An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Corey R. Hopkins; Nicola Collar

doi:10.1016/j.tetlet.2004.09.152

An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

Original language	English (US)
Pages (from-to)	8631-8633
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2004.09.152
State	Published - Nov 15 2004

Keywords

6-Substituted-5H-pyrrolo[2,3-b]pyrazine
Cyclization
Heteroannulation
Microwave
Palladium

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Hopkins, C. R., & Collar, N. (2004). An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating. Tetrahedron Letters, 45(47), 8631-8633. https://doi.org/10.1016/j.tetlet.2004.09.152

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abstract = "We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.",

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