An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Corey R. Hopkins; Nicola Collar

doi:10.1016/j.tetlet.2004.09.152

An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

Original language	English (US)
Pages (from-to)	8631-8633
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2004.09.152
State	Published - Nov 15 2004
Externally published	Yes

Keywords

6-Substituted-5H-pyrrolo[2,3-b]pyrazine
Cyclization
Heteroannulation
Microwave
Palladium

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.",

keywords = "6-Substituted-5H-pyrrolo[2,3-b]pyrazine, Cyclization, Heteroannulation, Microwave, Palladium",

author = "Hopkins, {Corey R.} and Nicola Collar",

year = "2004",

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doi = "10.1016/j.tetlet.2004.09.152",

language = "English (US)",

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T1 - An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

AU - Hopkins, Corey R.

AU - Collar, Nicola

PY - 2004/11/15

Y1 - 2004/11/15

N2 - We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

AB - We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

KW - 6-Substituted-5H-pyrrolo[2,3-b]pyrazine

KW - Cyclization

KW - Heteroannulation

KW - Microwave

KW - Palladium

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DO - 10.1016/j.tetlet.2004.09.152

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EP - 8633

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 47

ER -

An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Abstract

Keywords

ASJC Scopus subject areas

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