An improved synthesis of psammaplin A

Amy M. Godert, Norman Angelino, Anna Woloszynska-Read, Shannon R. Morey, Smitha R. James, Adam R. Karpf, Janice R. Sufrin

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.

Original languageEnglish (US)
Pages (from-to)3330-3333
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number12
DOIs
StatePublished - Jun 15 2006
Externally publishedYes

Keywords

  • 5-Bromo-psammaplin A
  • Cancer cells
  • DNA methylation
  • DNA methyltransferase
  • DNA methyltransferase inhibitor
  • Psammaplin A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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