TY - JOUR
T1 - An in vitro comparison of different providers to deliver four proton pump inhibitor products through a feeding tube
AU - Devlin, J. W.
AU - Bakshi, A.
AU - Bungay, K.
AU - Olsen, K. M.
PY - 2006/12
Y1 - 2006/12
N2 - Background: It is unclear how delivery through a feeding tube compares between esomeprazole in water, lansoprazole oral disintegrating tablet in water, omeprazole/NaHCO3 in water and simplified lansoprazole suspension. Aim: This in vitro study compared delivery through a narrow calibre (8F) feeding tube among four proton pump inhibitors when given by skilled [nurse; (n = 8)] or unskilled [lay; (n = 8)] providers. Methods: Following standard instruction, subjects were observed delivering each proton pump inhibitor in a sequential, but random, fashion to evaluate administration quality and time. Delivery was quantified using high-performance liquid chromatography methods and subject preferences were evaluated. Results: Delivery (%), similar between lansoprazole oral disintegrating tablet (95.7 ± 3.2) and omeprazole/NaHCO3 (96.1 ± 3.0), was both greater for lansoprazole oral disintegrating tablet than esomeprazole in water (88.9 ± 8.6; P = 0.006) or simplified lansoprazole suspension (86.1 ± 9.5; P = 0.0001) and omeprazole/ NaHCO3 than esomeprazole in water (P = 0.004) or simplified lansoprazole suspension (P < 0.001), and was not affected by prior subject experience. Quality was higher with both omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet than simplified lansoprazole suspension. Administration was quicker for lansoprazole oral disintegrating tablet than esomeprazole in water. Subjects preferred lansoprazole oral disintegrating tablet and omeprazole/NaHCO3. Conclusions: When given through an in vitro feeding tube, omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet lead to greater drug delivery, improved administration quality and higher user satisfaction, than either esomeprazole in water or simplified lansoprazole suspension.
AB - Background: It is unclear how delivery through a feeding tube compares between esomeprazole in water, lansoprazole oral disintegrating tablet in water, omeprazole/NaHCO3 in water and simplified lansoprazole suspension. Aim: This in vitro study compared delivery through a narrow calibre (8F) feeding tube among four proton pump inhibitors when given by skilled [nurse; (n = 8)] or unskilled [lay; (n = 8)] providers. Methods: Following standard instruction, subjects were observed delivering each proton pump inhibitor in a sequential, but random, fashion to evaluate administration quality and time. Delivery was quantified using high-performance liquid chromatography methods and subject preferences were evaluated. Results: Delivery (%), similar between lansoprazole oral disintegrating tablet (95.7 ± 3.2) and omeprazole/NaHCO3 (96.1 ± 3.0), was both greater for lansoprazole oral disintegrating tablet than esomeprazole in water (88.9 ± 8.6; P = 0.006) or simplified lansoprazole suspension (86.1 ± 9.5; P = 0.0001) and omeprazole/ NaHCO3 than esomeprazole in water (P = 0.004) or simplified lansoprazole suspension (P < 0.001), and was not affected by prior subject experience. Quality was higher with both omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet than simplified lansoprazole suspension. Administration was quicker for lansoprazole oral disintegrating tablet than esomeprazole in water. Subjects preferred lansoprazole oral disintegrating tablet and omeprazole/NaHCO3. Conclusions: When given through an in vitro feeding tube, omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet lead to greater drug delivery, improved administration quality and higher user satisfaction, than either esomeprazole in water or simplified lansoprazole suspension.
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U2 - 10.1111/j.1365-2036.2006.03169.x
DO - 10.1111/j.1365-2036.2006.03169.x
M3 - Article
C2 - 17206948
AN - SCOPUS:33845496309
SN - 0269-2813
VL - 24
SP - 1603
EP - 1611
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
IS - 11-12
ER -