Background: It is unclear how delivery through a feeding tube compares between esomeprazole in water, lansoprazole oral disintegrating tablet in water, omeprazole/NaHCO3 in water and simplified lansoprazole suspension. Aim: This in vitro study compared delivery through a narrow calibre (8F) feeding tube among four proton pump inhibitors when given by skilled [nurse; (n = 8)] or unskilled [lay; (n = 8)] providers. Methods: Following standard instruction, subjects were observed delivering each proton pump inhibitor in a sequential, but random, fashion to evaluate administration quality and time. Delivery was quantified using high-performance liquid chromatography methods and subject preferences were evaluated. Results: Delivery (%), similar between lansoprazole oral disintegrating tablet (95.7 ± 3.2) and omeprazole/NaHCO3 (96.1 ± 3.0), was both greater for lansoprazole oral disintegrating tablet than esomeprazole in water (88.9 ± 8.6; P = 0.006) or simplified lansoprazole suspension (86.1 ± 9.5; P = 0.0001) and omeprazole/ NaHCO3 than esomeprazole in water (P = 0.004) or simplified lansoprazole suspension (P < 0.001), and was not affected by prior subject experience. Quality was higher with both omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet than simplified lansoprazole suspension. Administration was quicker for lansoprazole oral disintegrating tablet than esomeprazole in water. Subjects preferred lansoprazole oral disintegrating tablet and omeprazole/NaHCO3. Conclusions: When given through an in vitro feeding tube, omeprazole/NaHCO3 and lansoprazole oral disintegrating tablet lead to greater drug delivery, improved administration quality and higher user satisfaction, than either esomeprazole in water or simplified lansoprazole suspension.
ASJC Scopus subject areas
- Pharmacology (medical)