An increased frequency of 13q deletions detected by fluorescence in situ hybridization and its impact on survival in children and adolescents with Burkitt lymphoma: Results from the Children's Oncology Group study CCG-5961

Marilu Nelson, Sherrie L. Perkins, Bhavana J. Dave, Peter F. Coccia, Julia A. Bridge, Elizabeth R. Lyden, Nyla A. Heerema, Mark A. Lones, Lauren Harrison, Mitchell S. Cairo, Warren G. Sanger

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Burkitt lymphoma (BL), an aggressive B-cell malignancy, is often curable with short intensive treatment regiments. Nearly all BLs contain rearrangements of the MYC/8q24 region; however, recent cytogenetic studies suggest that certain secondary chromosomal aberrations in BL correlate with an adverse prognosis. In this multi-centre study, the frequency and impact on clinical outcome of del(13q) and +7 in addition to MYC rearrangements as detected by fluorescence in situ hybridization (FISH) in children and adolescents with intermediate and high-risk BL registered on Children's Cancer Group study CCG-5961 were investigated. Analysis with 13q14.3 and 13q34 loci specific probes demonstrated deletions of 13q in 38/90 (42%) cases. The loss of either 13q14.3 or 13q34 alone occurred in 14% and 8% respectively, while 20% exhibited loss of both regions. Gain of chromosome 7 was observed in 7/68 (10%) cases and MYC rearrangements were detected in 84/90 (93%). Prognostic analysis controlling for known risk factors demonstrated that patients exhibiting loss of 13q, particularly 13q14.3, had a significant decrease in 5-year overall survival (77% vs. 95%, P = 0·012). These observations indicate that del(13q) occurs in childhood BL at frequencies higher than previously detected by classical cytogenetics and underscores the importance of molecular cytogenetics in risk stratification.

Original languageEnglish (US)
Pages (from-to)600-610
Number of pages11
JournalBritish Journal of Haematology
Volume148
Issue number4
DOIs
StatePublished - Feb 2010

Keywords

  • Burkitt lymphoma
  • Chromosome 13 deletion
  • Fluorescence in situ hybridization
  • Survival

ASJC Scopus subject areas

  • Hematology

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