An unexpectedly facile cyclization of polyhydric alcohols

Christopher Pavlik, Amber Onorato, Steve Castro, Martha Morton, Mark Peczuh, Michael B. Smith

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Image Presented Contrary to previous reports in the literature, the reaction of polyhydric alcohols such as sorbitol or mannitol gives good yields of the tetrahydroxyoxepane derivative in the presence of an acid catalyst, in refluxing toluene, with complete retention of stereochemistry.

Original languageEnglish (US)
Pages (from-to)3722-3725
Number of pages4
JournalOrganic Letters
Issue number16
StatePublished - Aug 20 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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