An unusual multiple drug intoxication case involving citalopram

K. Fu, R. J. Konrad, R. W. Hardy, R. M. Brissie, C. A. Robinson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A 47-year-old male with a history of drug abuse and suicide attempts was found dead at home. The death scene investigation showed evidence of cocaine abuse and multiple drug ingestion. Citralopram, a new selective serotonin reuptake inhibitor, cocaine, oxycodone, promethazine, propoxyphene, and norpropoxyphene were identified and quantitated in the postmortem samples by gas chromatography-mass spectrometry. The concentration of citalopram in the femoral blood was 0.88 mg/L. The heart blood concentration was 1.16 mg/L. Femoral blood concentrations of the other drugs were as follows: cocaine, 0.03 mg/L; oxycodone, 0.06 mg/L; promethazine, 0.02 mg/L; propoxyphene, 0.02 mg/L; and norpropoxyphene, 0.07 mg/L. Other tissue samples were also analyzed. The concentrations of cocaine, oxycodone, promethazine, and propoxyphene in the blood, liver, brain, and gastric contents did not suggest an intentional overdose. However, the possibility of multiple drug interactions including citalopram was evident. In this case, the citalopram concentrations were consistent with those reported in fatal cases involving multiple drug use. Citalopram was present in urine at a concentration of 0.9 mg/L.

Original languageEnglish (US)
Pages (from-to)648-650
Number of pages3
JournalJournal of Analytical Toxicology
Volume24
Issue number7
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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    Fu, K., Konrad, R. J., Hardy, R. W., Brissie, R. M., & Robinson, C. A. (2000). An unusual multiple drug intoxication case involving citalopram. Journal of Analytical Toxicology, 24(7), 648-650. https://doi.org/10.1093/jat/24.7.648