An update on tuberculosis

Bradford A. Becken, Fernando J. Bula Rudas, Archana Chatterjee

Research output: Chapter in Book/Report/Conference proceedingChapter


Mycobacterium tuberculosis remains the leading cause of death from a single infectious agent worldwide. Since its isolation, much has been learned about the disease; however, social determinants of health, microbiology, and pharmacology keep tuberculosis at the forefront of public health. More than 10 million individuals become ill with tuberculosis every year, and over 1 million of those will die annually. Mycobacteria spread through airborne droplets, therefore tuberculosis affects areas where people have close human contact and is significantly impacted by economic and social disparities. Pulmonary tuberculosis is the more common form of active disease but extrapulmonary dissemination may occur and may lead to significant morbidity and mortality. Antimicrobial treatment for tuberculosis may be problematic and the continuous evolution of resistant strains contributing to current and future challenges in management. Continuous funding for research is needed for the development of new antimicrobial agents and tools for its management and prevention.

Original languageEnglish (US)
Title of host publicationViral, Parasitic, Bacterial, and Fungal Infections
Subtitle of host publicationAntimicrobial, Host Defense, and Therapeutic Strategies
Number of pages10
ISBN (Electronic)9780323857307
ISBN (Print)9780323898003
StatePublished - Jan 1 2022


  • Multidrug-resistant tuberculosis
  • Mycobacterium tuberculosis
  • Tuberculosis

ASJC Scopus subject areas

  • General Medicine


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