Abstract
A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.
Original language | English (US) |
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Pages (from-to) | 6262-6265 |
Number of pages | 4 |
Journal | Analyst |
Volume | 138 |
Issue number | 21 |
DOIs | |
State | Published - Nov 7 2013 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Environmental Chemistry
- Spectroscopy
- Electrochemistry