TY - JOUR
T1 - Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations
AU - Xu, Zheng
AU - Duan, Qing
AU - Cui, Juan
AU - Qiu, Yumou
AU - Jia, Qidong
AU - Wu, Cong
AU - Clarke, Jennifer
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/9/17
Y1 - 2018/9/17
N2 - Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different groups have different drug sensitivities and, consequently, there are differences in drug effects. In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine.
AB - Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different groups have different drug sensitivities and, consequently, there are differences in drug effects. In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine.
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U2 - 10.1186/s12919-018-0153-6
DO - 10.1186/s12919-018-0153-6
M3 - Article
C2 - 30275894
AN - SCOPUS:85053406902
SN - 1753-6561
VL - 12
JO - BMC Proceedings
JF - BMC Proceedings
M1 - 46
ER -