Analysis of prognostic factors in acute lymphoblastic leukemia

Denman Hammond, Harland Sather, Mark Nesbit, Dennis Miller, Peter Coccia, Archie Bleyer, John Lukens, Stuart Siegel

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Children with ALL who have a high probability of excellent response, long‐term survival, and cure when treated with widely available standard therapy can be identified at the time of diagnosis. Others can be identified who are at high risk of failure to respond, early relapse, and death. The importance of such prognostic characteristics is so great that they should be considered in the selection of appropriate treatment for each patient. Prognostic factors also must be considered in the design and analysis of clinical trials. All prognostic factors are not equally significant and many of them are closely associated. It is possible to rank them in importance and usefulness by appropriate statistical methods. As additional prognostic factors are identified, and as more effective and more specific therapies are developed, the relative importance of prognostic factors will change.

Original languageEnglish (US)
Pages (from-to)124-134
Number of pages11
JournalMedical and Pediatric Oncology
Volume14
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • acute lymphoblastic leukemia
  • prognostic factors
  • relative importance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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  • Cite this

    Hammond, D., Sather, H., Nesbit, M., Miller, D., Coccia, P., Bleyer, A., Lukens, J., & Siegel, S. (1986). Analysis of prognostic factors in acute lymphoblastic leukemia. Medical and Pediatric Oncology, 14(3), 124-134. https://doi.org/10.1002/mpo.2950140305