Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients

An Chi Lo, Ageliki Georgopoulos, Celina G. Kleer, Mousumi Banerjee, Sherif Omar, Hussein Khaled, Saad Eissa, Ahmed Hablas, Hoda G. Omar, Julie A. Douglas, Sofia D. Merajver, Amr S. Soliman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Understanding the molecular factors that distinguish inflammatory breast cancer (IBC) from non-IBC is important for IBC diagnosis. We reviewed the records of 48 IBC patients and 64 non-IBC patients from Egypt. We determined RhoC expression and tumor emboli and their relationship to demographic and reproductive characteristics. Compared with non-IBC patients, IBC patients had significantly lower parity (P = 0.018) and fewer palpable tumors (P < 0.0001). IBC tumors showed RhoC overexpression more frequently than non-IBC tumors (87% vs. 17%, respectively) (P < 0.0001). Tumor emboli were significantly more frequent in IBC tumors than non-IBC tumors (Mean ± SD: 14.1 ± 14.0 vs. 7.0 ± 12.9, respectively) (P < 0.0001). This study illustrates that RhoC overexpression and tumor emboli are more frequent in tumors of IBC relative to non-IBC from Egypt. Future studies should focus on relating epidemiologic factors to molecular features of IBC in this population.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalBreast
Volume18
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Developing countries
  • Egypt
  • Inflammatory breast cancer
  • RhoC
  • Tumor emboli

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients'. Together they form a unique fingerprint.

  • Cite this

    Lo, A. C., Georgopoulos, A., Kleer, C. G., Banerjee, M., Omar, S., Khaled, H., Eissa, S., Hablas, A., Omar, H. G., Douglas, J. A., Merajver, S. D., & Soliman, A. S. (2009). Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients. Breast, 18(1), 55-59. https://doi.org/10.1016/j.breast.2008.11.002