Abstract
A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong, sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.
Original language | English (US) |
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Pages (from-to) | 111-113 |
Number of pages | 3 |
Journal | Gene |
Volume | 167 |
Issue number | 1-2 |
DOIs | |
State | Published - Dec 29 1995 |
Externally published | Yes |
Keywords
- Peptidoglycan
- carboxypeptidase
- cross-linking
- transpeptidase
ASJC Scopus subject areas
- Genetics