Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter

T. L. Domanski, K. W. Bayles

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong, sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.

Original languageEnglish (US)
Pages (from-to)111-113
Number of pages3
JournalGene
Volume167
Issue number1-2
DOIs
StatePublished - Dec 29 1995
Externally publishedYes

Keywords

  • Peptidoglycan
  • carboxypeptidase
  • cross-linking
  • transpeptidase

ASJC Scopus subject areas

  • Genetics

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