Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques

Vanessa Rivera-Amill; Richard J. Noel; Ivelisse Rivera Román; Yashira García Flores; Shilpa Buch; Anil Kumar

doi:10.1089/aid.2008.0279

Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques

Vanessa Rivera-Amill, Richard J. Noel, Ivelisse Rivera Román, Yashira García Flores, Shilpa Buch, Anil Kumar

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent group along with that in the control group was assessed. Six to 10 clones from the brain of each macaque were sequenced and were compared against each other as well as against a challenge virus. Analysis of the sequences revealed that the diversity and divergence of the clones were higher in the control group as compared to the morphine-dependent macaques, although this difference was not statistically significant.

Original language	English (US)
Pages (from-to)	531-534
Number of pages	4
Journal	AIDS Research and Human Retroviruses
Volume	25
Issue number	5
DOIs	https://doi.org/10.1089/aid.2008.0279
State	Published - May 1 2009
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.2008.0279

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abstract = "Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent group along with that in the control group was assessed. Six to 10 clones from the brain of each macaque were sequenced and were compared against each other as well as against a challenge virus. Analysis of the sequences revealed that the diversity and divergence of the clones were higher in the control group as compared to the morphine-dependent macaques, although this difference was not statistically significant.",

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AU - Román, Ivelisse Rivera

AU - Flores, Yashira García

AU - Buch, Shilpa

AU - Kumar, Anil

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Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques

Abstract

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