TY - GEN
T1 - Analyzing T cell receptor alpha/beta usage in binding to the pMHC
AU - Ehrlich, Ryan
AU - Ghersi, Dario
N1 - Funding Information:
ACKNOWLEDGMENT The authors would like to thank Drs. Liisa Selin and Katherine Luzuriaga and their groups at the University of Massachusetts Medical School for useful discussions on heterologous immunity. This work was partly funded by a Nebraska Research Initiative grant to DG.
Publisher Copyright:
© 2017 IEEE.
PY - 2017/12/15
Y1 - 2017/12/15
N2 - T cells play a critical role in the adaptive immune response. They perform their function by recognizing infected cells presenting peptides on a specialized complex known as the MHC. The recognition process involves binding of the peptideloaded MHC to the T cell receptor (TCR), a surface molecule comprised of an alpha and a beta chain. A large body of evidence suggests that T cells can respond to previously unseen pathogens, a phenomenon known as cross-reactivity. Crossreactivity has important medical implications, as cross-reactive responses can be either protective or lead to disease. A possible mechanism that has been proposed to explain cross-reactivity is the differential usage of the alpha and beta chains, whereas one peptide can be recognized predominantly by the alpha chain and a different peptide by the beta chain. In this study we carry out a systematic analysis of a non-redundant set of 67 crystal structures, measuring TCR alpha/beta usage and its relationship with structural features of the interaction. Our results show a wide range of TCR alpha/beta usage in different complexes. Further, we find that alpha/beta usage significantly correlates with one of the docking angles between the TCR and the MHC.
AB - T cells play a critical role in the adaptive immune response. They perform their function by recognizing infected cells presenting peptides on a specialized complex known as the MHC. The recognition process involves binding of the peptideloaded MHC to the T cell receptor (TCR), a surface molecule comprised of an alpha and a beta chain. A large body of evidence suggests that T cells can respond to previously unseen pathogens, a phenomenon known as cross-reactivity. Crossreactivity has important medical implications, as cross-reactive responses can be either protective or lead to disease. A possible mechanism that has been proposed to explain cross-reactivity is the differential usage of the alpha and beta chains, whereas one peptide can be recognized predominantly by the alpha chain and a different peptide by the beta chain. In this study we carry out a systematic analysis of a non-redundant set of 67 crystal structures, measuring TCR alpha/beta usage and its relationship with structural features of the interaction. Our results show a wide range of TCR alpha/beta usage in different complexes. Further, we find that alpha/beta usage significantly correlates with one of the docking angles between the TCR and the MHC.
UR - http://www.scopus.com/inward/record.url?scp=85046035954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046035954&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2017.8217629
DO - 10.1109/BIBM.2017.8217629
M3 - Conference contribution
AN - SCOPUS:85046035954
T3 - Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
SP - 83
EP - 87
BT - Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
A2 - Yoo, Illhoi
A2 - Zheng, Jane Huiru
A2 - Gong, Yang
A2 - Hu, Xiaohua Tony
A2 - Shyu, Chi-Ren
A2 - Bromberg, Yana
A2 - Gao, Jean
A2 - Korkin, Dmitry
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Y2 - 13 November 2017 through 16 November 2017
ER -