TY - JOUR
T1 - Anaplastic lymphoma kinase
T2 - Role in cancer and therapy perspective
AU - Zhao, Zhihong
AU - Verma, Vivek
AU - Zhang, Mutian
N1 - Publisher Copyright:
© 2015 Taylor & Francis Group, LLC.
PY - 2015/12/2
Y1 - 2015/12/2
N2 - Anaplastic lymphoma kinase (ALK) is correlated with oncogenesis in different types of cancers, such as anaplastic large cell lymphoma, lung cancer, neuroblastoma, and even breast cancer, by abnormal fusion of ALK or non-fusion ALK activation. ALK is a receptor tyrosine kinase, with a single transmembrane domain, that plays an important role in development. Upon ligand binding to the extracellular domain, the receptor undergoes dimerization and subsequent autophosphorylation of the intracellular kinase domain. In recent years, ALK inhibitors have been developed for cancer treatment. These inhibitors target ALK activity and show effectiveness in ALK-positive non-small cell lung cancer. However, acquired treatment resistance makes the future of this therapy unclear; new strategies are underway to overcome the limitations of current ALK inhibitors.
AB - Anaplastic lymphoma kinase (ALK) is correlated with oncogenesis in different types of cancers, such as anaplastic large cell lymphoma, lung cancer, neuroblastoma, and even breast cancer, by abnormal fusion of ALK or non-fusion ALK activation. ALK is a receptor tyrosine kinase, with a single transmembrane domain, that plays an important role in development. Upon ligand binding to the extracellular domain, the receptor undergoes dimerization and subsequent autophosphorylation of the intracellular kinase domain. In recent years, ALK inhibitors have been developed for cancer treatment. These inhibitors target ALK activity and show effectiveness in ALK-positive non-small cell lung cancer. However, acquired treatment resistance makes the future of this therapy unclear; new strategies are underway to overcome the limitations of current ALK inhibitors.
KW - anaplastic lymphoma kinase
KW - cancer
KW - inhibitor
KW - resistance
KW - therapy
KW - tyrosine kinase
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U2 - 10.1080/15384047.2015.1095407
DO - 10.1080/15384047.2015.1095407
M3 - Article
C2 - 26529396
AN - SCOPUS:84954554286
SN - 1538-4047
VL - 16
SP - 1691
EP - 1701
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
IS - 12
ER -