Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

Daniel T. Monaghan, Amy L. Buller

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter compares the anatomical and pharmacological properties of the recombinant NMDA receptor subunits with the properties of native NMDA receptor subtypes. It first summarizes the anatomical distribution of individual receptor subunits and then compares their distributions with those of NMDA receptor subtypes identified in radio ligand binding studies. Radioligand binding studies indicate the presence of at least four pharmacologically distinct populations of NMDA receptors with differing regional distributions. There is substantial regional variation among members of both the NR1 and NR2 subunit families; however, the distributions of the NR2 subunits correspond much more closely to the distributions of the pharmacologically distinct NMDA receptor populations.

Original languageEnglish (US)
Title of host publicationThe NMDA Receptor
PublisherOxford University Press
ISBN (Electronic)9780191724701
ISBN (Print)9780192625021
DOIs
StatePublished - Mar 22 2012

Keywords

  • Anatomical features
  • Ligand binding
  • NDMA receptors
  • Pharmacological properties
  • Receptor subtypes

ASJC Scopus subject areas

  • Neuroscience(all)

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