Androgen-dependent peptides of the rat ventral prostate nuclear envelope

Jaya T. Venkatraman, Gillian M. Howell, Yvonne A. Lefebvre

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Nuclear envelope peptides of the rat ventral prostate in the molecular weight region 18,400 to 19,400 show marked androgen dependence. After castration these peptides disappear. Re-administration of testosterone restores them. They were not extracted by 0.1 M NaCl or 5% HClO4 but were partially extracted by 0.35 M NaCl and 1% Triton. These peptides were not present in rat liver nuclear envelopes. As these androgen-dependent non-histone peptides have similar characteristics to androgen-dependent peptides identified in the prostate nucleus, we conclude that the nuclear peptides are at least partially localized to the nuclear envelope.

Original languageEnglish (US)
Pages (from-to)469-474
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume125
Issue number2
DOIs
StatePublished - Dec 14 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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