Angiotensin and carotid body chemoreception in heart failure

Harold D. Schultz

doi:10.1016/j.coph.2010.12.004

Angiotensin and carotid body chemoreception in heart failure

Harold D. Schultz

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.

Original language	English (US)
Pages (from-to)	144-149
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.coph.2010.12.004
State	Published - Apr 2011

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.coph.2010.12.004

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title = "Angiotensin and carotid body chemoreception in heart failure",

abstract = "The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.",

author = "Schultz, {Harold D.}",

note = "Funding Information: This study was supported by a Program Project Grant from the Heart, Lung and Blood Institute of NIH ( PO1-HL62222 ). ",

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N2 - The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.

AB - The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.

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Angiotensin and carotid body chemoreception in heart failure

Abstract

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