Angiotensin and carotid body chemoreception in heart failure

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume11
Issue number2
DOIs
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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