Animal models of cancer-associated cachexia

Surendra Kumar Shukla, Pankaj Kumar Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Cachexia is a complex metabolic disorder associated with several chronic diseases, including cancer. Cachexia-associated complications, including muscle wasting, fat depletion, immobility, severe impairment of respiratory muscles, and cardiopulmonary failure, contribute to significant mortality in cancer patients. Currently, there is no FDA (Food and Drug Administration)-approved treatment for cachexia. The key factor for the lack of anticachectic therapy is the complexity of this disease and its variable nature. The clinical end points of cachexia are poorly defined, and a scarcity of information exists regarding the exact underlying molecular mechanisms of cancer-associated cachexia. The use of improved, physiologically relevant models of cancer-induced cachexia will improve our understanding of underlying molecular mechanism of cancer-induced cachexia and provide a platform to evaluate novel therapeutic agents. The focus of the current chapter is to provide updated information about the different animal models currently in use to study of cancer-associated cachexia.

Original languageEnglish (US)
Title of host publicationAnimal Models in Cancer Drug Discovery
PublisherElsevier
Pages59-74
Number of pages16
ISBN (Electronic)9780128147054
ISBN (Print)9780128147047
DOIs
StatePublished - Apr 17 2019

Keywords

  • Cachexia
  • Cytokines
  • Fat depletion
  • Muscle wasting
  • Proteolysis

ASJC Scopus subject areas

  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)

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    Shukla, S. K., & Singh, P. K. (2019). Animal models of cancer-associated cachexia. In Animal Models in Cancer Drug Discovery (pp. 59-74). Elsevier. https://doi.org/10.1016/B978-0-12-814704-7.00001-5