Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention

D. B. McNamara, S. N. Murthy, A. N. Fonseca, C. V. Desouza, P. J. Kadowitz, V. A. Fonseca

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Diabetes is a complex disorder characterized by impaired insulin formation, release or action (insulin resistance), elevated blood glucose, and multiple long-term complications. It is a common endocrine disorder of humans and is associated with abnormalities of carbohydrate and lipid metabolism. There are two forms of diabetes, classified as type 1 and type 2. In type 1 diabetes, hyperglycemia is due to an absolute lack of insulin, whereas in type 2 diabetes, hyper- glycemia is due to a relative lack of insulin and insulin resistance. More than 90% of people with diabetes have type 2 with varied degrees of insulin resistance. Insulin resistance is often associated with impaired insulin secretion, and hyper- glycemia is a common feature in both types of diabetes, but failure to make a distinction between the types of diabetes in different animal models has led to confusion in the literature. This is particularly true in relation to cardiovascular disease in the presence of diabetes and especially the response to vascular injury, in which there are major differences between the two types of diabetes. Animal models do not completely mimic the clinical disease seen in humans. Animal models are at best analogies of the pathologic process they are designed to represent. The focus of this review is an analysis of in- timal hyperplasia following catheter-induced vascular injury, including factors that may complicate comparisons between different animal models or between in vitro and in vivo studies. We examine the variables, pitfalls, and caveats that follow from the manner of induction of the injury and the diabetic state of the animal. The efficacy of selected antidiabetic drugs in inhibiting the development of the hyperplastic response is also discussed.

Original languageEnglish (US)
Pages (from-to)37-50
Number of pages14
JournalCanadian journal of physiology and pharmacology
Volume87
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Keywords

  • Animal models
  • Catheter injury
  • Diabetes
  • Hyperglycemia
  • Incretin mimetics
  • Insulin
  • Intimal hyperplasia
  • Niacin
  • Ppar agonist
  • Sildenafil

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention'. Together they form a unique fingerprint.

Cite this