Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes

Olga Taraschenko; Swetha Pedavally; Kaeli K. Samson; Mark J. Puccioni; Deepak Madhavan

doi:10.1016/j.ebcr.2017.12.001

Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes

Olga Taraschenko, Swetha Pedavally, Kaeli K. Samson, Mark J. Puccioni, Deepak Madhavan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic–clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG.

Original language	English (US)
Pages (from-to)	12-18
Number of pages	7
Journal	Epilepsy and Behavior Case Reports
Volume	9
DOIs	https://doi.org/10.1016/j.ebcr.2017.12.001
State	Published - 2018

Keywords

Corpus callosotomy
Epilepsy surgery
Intracranial EEG
Refractory seizures

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

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10.1016/j.ebcr.2017.12.001

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title = "Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes",

abstract = "Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic–clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG.",

keywords = "Corpus callosotomy, Epilepsy surgery, Intracranial EEG, Refractory seizures",

author = "Olga Taraschenko and Swetha Pedavally and Samson, {Kaeli K.} and Puccioni, {Mark J.} and Deepak Madhavan",

note = "Funding Information: O. Taraschenko receives salary support from the University of Nebraska College of Medicine Physician–Scientist Training Award. K.K. Samson and S. Pedavally report no disclosures. M. Puccioni serves as an educator for Neuropace and receives compensation for educational activities for LivaNova. D. Madhavan is a paid consultant for LivaNova. Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2018",

doi = "10.1016/j.ebcr.2017.12.001",

language = "English (US)",

volume = "9",

pages = "12--18",

journal = "Epilepsy and Behavior Case Reports",

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T1 - Anterior corpus callosotomy in patients with drug-resistant epilepsy

T2 - Invasive EEG findings and seizure outcomes

AU - Taraschenko, Olga

AU - Pedavally, Swetha

AU - Samson, Kaeli K.

AU - Puccioni, Mark J.

AU - Madhavan, Deepak

N1 - Funding Information: O. Taraschenko receives salary support from the University of Nebraska College of Medicine Physician–Scientist Training Award. K.K. Samson and S. Pedavally report no disclosures. M. Puccioni serves as an educator for Neuropace and receives compensation for educational activities for LivaNova. D. Madhavan is a paid consultant for LivaNova. Publisher Copyright: © 2017 The Authors

PY - 2018

Y1 - 2018

N2 - Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic–clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG.

AB - Corpus callosotomy (CC) is used in patients with drug-resistant seizures who are not candidates for excisional surgery and failed neurostimulation. We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic–clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG.

KW - Corpus callosotomy

KW - Epilepsy surgery

KW - Intracranial EEG

KW - Refractory seizures

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JO - Epilepsy and Behavior Case Reports

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ER -

Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes

Abstract

Keywords

ASJC Scopus subject areas

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