Abstract
The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain Mclntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.
Original language | English (US) |
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Pages (from-to) | 393-399 |
Number of pages | 7 |
Journal | Brain Research Bulletin |
Volume | 28 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1992 |
Externally published | Yes |
Keywords
- Anterograde
- Herpes simplex virus (HSV)
- Lateral geniculate nucleus
- Superior colliculus
- Suprachiasmatic nucleus
- Transneuronal
- Visual system
ASJC Scopus subject areas
- General Neuroscience