Anterograde transport of HSV-1 and HSV-2 in the visual system

Robert B. Norgren, John H. McLean, H. Curt Bubel, Arden Wander, David I. Bernstein, Michael N. Lehman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain Mclntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalBrain Research Bulletin
Issue number3
StatePublished - Mar 1992
Externally publishedYes


  • Anterograde
  • Herpes simplex virus (HSV)
  • Lateral geniculate nucleus
  • Superior colliculus
  • Suprachiasmatic nucleus
  • Transneuronal
  • Visual system

ASJC Scopus subject areas

  • General Neuroscience


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