Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

Guangshun Wang, Karen M. Watson, Robert W. Buckheit

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

Original languageEnglish (US)
Pages (from-to)3438-3440
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number9
DOIs
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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