Anti-nlrp3 inflammasome natural compounds: An update

Baolong Liu, Jiujiu Yu

Research output: Contribution to journalReview articlepeer-review

Abstract

The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment, leading to activation of caspase-1 and inducing inflammatory responses. This pro-inflammatory protein complex plays critical roles in pathogenesis of a wide range of diseases including neurodegenerative diseases, autoinflammatory diseases, and metabolic disorders. Therefore, intensive efforts have been devoted to understanding its activation mechanisms and to searching for its specific inhibitors. Approximately forty natural compounds with anti-NLRP3 inflammasome properties have been identified. Here, we provide an update about new natural compounds that have been identified within the last three years to inhibit the NLRP3 inflammasome and offer an overview of the underlying molecular mechanisms of their anti-NLRP3 inflammasome activities.

Original languageEnglish (US)
Article number136
Pages (from-to)1-19
Number of pages19
JournalBiomedicines
Volume9
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Inflammatory diseases
  • Medicinal herbs
  • Natural compounds
  • NLRP3 inflammasome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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