Antibiotic pharmacodynamics for clinicians: A summary of the basics

Keith M. Olsen, Kyle Skiermont, G. Douglas Campbell

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

For an antimicrobial agent to be effective, it must reach the site of infection in sufficient concentration and duration to inhibit pathogen growth. While the minimum inhibitory concentration (MIC) reflects an organism's in vitro susceptibility to an antibiotic, it does not predict drug concentration at the site of infection. Certain classes of antibiotics are more effective in killing pathogens as their peak serum concentration above the MIC is increased (concentration-dependent killing), while others are more effective the longer the antibiotic concentration remains above the pathogen's MIC (time-dependent killing). The fluoroquinolones and aminoglycosides exhibit concentration-dependent killing. Penicillins, carbapenems, cephalosporins, and macrolides - with the exception of azithromycin - display time-dependent killing. In the treatment of pulmonary infections, an antibiotic must cross the blood-bronchoalveolar barrier and enter the epithelial lining fluid. Antibiotics that accomplish this include azithromycin, clarithromycin, and the fluoroquinolones.

Original languageEnglish (US)
Pages (from-to)561-568
Number of pages8
JournalJournal of Respiratory Diseases
Volume23
Issue number11
StatePublished - Nov 1 2002

Keywords

  • AUC/MIC ratios of fluoroquinolones for respiratory pathogens
  • Concentrations of antibiotics in serum and pulmonary tissue
  • Minimum inhibitory concentrations
  • Pharmacodynamic parameters
  • Pharmacodynamic ratios that correspond to antibacterial efficacy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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