Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: Relationship to colonization status and infection in the neonate

H. Dele Davies, Carol Adair, Alison McGeer, Doreen Ma, Sheila Robertson, Melissa Mucenski, Laura Kowalsky, Gregory Tyrell, Carol J. Baker

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

In a cohort study of 1207 pregnant women in Alberta, Canada, the serotype distributions of vaginal-rectal group B Streptococcus (GBS) isolates were compared with all isolates from neonates with invasive GBS disease identified by population-based surveillance. Serum concentrations of Ia, Ib, II, III, and V capsular polysaccharide (CPS)-specific IgG also were determined, according to serotype of the vaginal-rectal colonizing GBS strain. GBS colonization was detected in 19.5% (235 of 1207) of women. Serotype III accounted for 20.6% (48 of 233) of colonizing strains available for typing but for 37% (27 of 73) of invasive isolates from neonates (P < .01). Maternal colonization with type III was least likely to be associated with moderate concentrations of III CPS-specific IgG. Serotype III GBS is more invasive than other serotypes in this population; this may be due, at least in part, to poor maternal type III CPS-specific antibody response.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalJournal of Infectious Diseases
Volume184
Issue number3
DOIs
StatePublished - Aug 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: Relationship to colonization status and infection in the neonate'. Together they form a unique fingerprint.

  • Cite this