TY - JOUR
T1 - Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women
T2 - Relationship to colonization status and infection in the neonate
AU - Davies, H. Dele
AU - Adair, Carol
AU - McGeer, Alison
AU - Ma, Doreen
AU - Robertson, Sheila
AU - Mucenski, Melissa
AU - Kowalsky, Laura
AU - Tyrell, Gregory
AU - Baker, Carol J.
N1 - Funding Information:
Financial support: Alberta Heritage Foundation (grant 199500534); National Health Research and Development Program (grant 6606-5645-502); Canadian Institutes of Health Research (formerly Medical ResearchCouncil of Canada [grant MT-15026]); US National Institutes of Health (contract AI 15126).
PY - 2001/8/1
Y1 - 2001/8/1
N2 - In a cohort study of 1207 pregnant women in Alberta, Canada, the serotype distributions of vaginal-rectal group B Streptococcus (GBS) isolates were compared with all isolates from neonates with invasive GBS disease identified by population-based surveillance. Serum concentrations of Ia, Ib, II, III, and V capsular polysaccharide (CPS)-specific IgG also were determined, according to serotype of the vaginal-rectal colonizing GBS strain. GBS colonization was detected in 19.5% (235 of 1207) of women. Serotype III accounted for 20.6% (48 of 233) of colonizing strains available for typing but for 37% (27 of 73) of invasive isolates from neonates (P < .01). Maternal colonization with type III was least likely to be associated with moderate concentrations of III CPS-specific IgG. Serotype III GBS is more invasive than other serotypes in this population; this may be due, at least in part, to poor maternal type III CPS-specific antibody response.
AB - In a cohort study of 1207 pregnant women in Alberta, Canada, the serotype distributions of vaginal-rectal group B Streptococcus (GBS) isolates were compared with all isolates from neonates with invasive GBS disease identified by population-based surveillance. Serum concentrations of Ia, Ib, II, III, and V capsular polysaccharide (CPS)-specific IgG also were determined, according to serotype of the vaginal-rectal colonizing GBS strain. GBS colonization was detected in 19.5% (235 of 1207) of women. Serotype III accounted for 20.6% (48 of 233) of colonizing strains available for typing but for 37% (27 of 73) of invasive isolates from neonates (P < .01). Maternal colonization with type III was least likely to be associated with moderate concentrations of III CPS-specific IgG. Serotype III GBS is more invasive than other serotypes in this population; this may be due, at least in part, to poor maternal type III CPS-specific antibody response.
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U2 - 10.1086/322029
DO - 10.1086/322029
M3 - Article
C2 - 11443553
AN - SCOPUS:0035425576
VL - 184
SP - 285
EP - 291
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -