Antibodies to laminin in Chagas' disease

A. Szarfman, V. P. Terranova, S. I. Rennard, J. M. Foidart, M. de Fatima Lima, J. I. Scheinman, G. R. Martin

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

We have found that sera from humans with Chagas' disease and Rhesus monkeys infected with Trypanosoma cruzi contain IgM and IgG antibodies, which react with structures in a variety of connective tissues. These antibodies react with laminin but not with various other purified connective tissue components like collagen types I, III, IV, and V, fibronectin, heparan sulfate (BM-1) proteoglycan, or chondronectin. The tissue-reacting antibodies were isolated by absorption to a laminin-Sepharose column. The bound fraction contained all the tissue-reacting antibodies. These antibodies strongly stained trypomastigotes and amastigotes, but weakly stained trypomastigotes and mastigotes, but weakly stained epimastigotes. These studies show that sera from T. cruzi-infected primates contain antilaminin antibodies, which may be produced by those host in response to a laminin-like molecule present in the parasite.

Original languageEnglish (US)
Pages (from-to)1161-1171
Number of pages11
JournalJournal of Experimental Medicine
Volume155
Issue number4
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Antibodies to laminin in Chagas' disease'. Together they form a unique fingerprint.

  • Cite this

    Szarfman, A., Terranova, V. P., Rennard, S. I., Foidart, J. M., de Fatima Lima, M., Scheinman, J. I., & Martin, G. R. (1982). Antibodies to laminin in Chagas' disease. Journal of Experimental Medicine, 155(4), 1161-1171. https://doi.org/10.1084/jem.155.4.1161