Antibody classes and subclasses in circulating immune complexes isolated from mice infected with lactic dehydrogenase virus

T. L. McDonald, T. Donnelly, A. Weber, L. Quenette

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A chronological study of circulating immune complexes (CIC) in lactic dehydrogenase virus (LDV)-infected mice has been performed. The results demonstrate that CIC containing immunoglobulin of the IgM class were isolated between days 3 and 9 post-LDV infection and corresponded to an increase in serum IgM. IgG1-containing CIC were also transient in the serum of LDV-infected mice in that they were isolated only between days 5 and 13. The occurrence of IgG1 CIC did correlate with an increase in total IgG1 in the serum, however it did correlate with a small (1:10) increase in IgG1 anti LDV activity. In contrast, CIC containing immunoglobulin of the serum IgG2 subclass were not isolated from LDV-infected serum until 15 days post infection. This chronological appearance of IgG2 CIC did not correlate with the observed increase in total IgG2 concentration in LDV-infected mice on day 7, however, was analogous to the rapid increase in free serum LDV-specific antibody. We propose that the non-specific suppression of the immune response and tumour enhancement during the acute phase of LDV infection could be due to the immunoregulatory properties of IgG1 CIC.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalImmunology
Volume48
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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