Antibody cross-linking of the thymocyte-specific cell surface molecule CTX causes abnormal mitosis and multinucleation of tumor cells

Jacques Robert, Deborah M. Brown, Louis Du Pasquier, Nicholas Cohen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The thymocyte-specific cell surface molecule CTX is a developmentally regulated type I transmembrane protein of the immunoglobulin superfamily which, in the amphibian Xenopus, is exclusively expressed by a large fraction of cortical thymocytes and by different cell lines derived from independent spontaneous thymic tumors. Antibody cross-linking of CTX in vitro inhibits the growth of tumor cells and causes morphological alterations. Cells divide abnormally, accumulate in the G2/M phase of the cell cycle, and become multi- nucleated. This demonstrates, for the fast time, that multinucleation can be induced by specifically cross-linking a cell surface molecule.

Original languageEnglish (US)
Pages (from-to)227-237
Number of pages11
JournalExperimental Cell Research
Volume235
Issue number1
DOIs
StatePublished - Aug 25 1997

ASJC Scopus subject areas

  • Cell Biology

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