TY - JOUR
T1 - Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis
AU - Mikuls, Ted R.
AU - Payne, Jeffrey B.
AU - Reinhardt, Richard A.
AU - Thiele, Geoffrey M.
AU - Maziarz, Eileen
AU - Cannella, Amy C.
AU - Holers, V. Michael
AU - Kuhn, Kristine A.
AU - O'Dell, James R.
N1 - Funding Information:
The authors wish to thank Dr. William McArthur (University of Florida, College of Dentistry, Gainesville, FL, USA) for his assistance in the measurement of P. gingivalis antibody and investigators and patients from the Rheumatoid Arthritis Investigational Network (RAIN) and UNMC College of Dentistry clinics for contributing to this effort. This work was supported by a grant from the UNMC Clinical Research Center. Dr. Mikuls receives research support from NIH/NIAMS (K23 AR050004-01A1 and R03 AR054539-01) and the Arthritis Foundation (Arthritis Investigator Award). Dr. Holers' efforts were supported by NIH (RO1 AR051394).
PY - 2009/1
Y1 - 2009/1
N2 - Summary: Antibody titers to P. gingivalis are increased in patients with rheumatoid arthritis and are associated with disease-specific autoimmunity. Background: Periodontitis (PD) has been implicated as a risk factor for rheumatoid arthritis (RA). We sought to characterize antibody titers to P. gingivalis (a pathogen in PD) in subjects with RA, PD, and in healthy controls and to examine their relationship with disease autoantibodies. Methods: P. gingivalis antibody was measured in subjects with RA (n = 78), PD (n = 39), and in controls (n = 40). Group frequencies of bacterial titer elevations were compared using the Chi-square test and antibody titers were compared using non-parametric tests. Correlations of P. gingivalis titer with C-reactive protein (CRP), antibody to cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) were examined in those with RA while CRP and autoantibody concentrations were compared based on seropositivity to P. gingivalis. Results: Antibody titers to P. gingivalis were highest in PD, lowest in controls, and intermediate in RA (p = 0.0003). Elevations in P. gingivalis (titer ≥ 800) were more common in RA and PD (67% and 77%, respectively) than in controls (40%) (p = 0.002). In RA, there were significant correlations with P. gingivalis titer with CRP, anti-CCP-IgM, and -IgG-2. CRP (p = 0.006), anti-CCP-IgM (p = 0.01) and -IgG2 (p = 0.04) concentrations were higher in RA cases with P. gingivalis titers ≥ 800 compared to cases with titers < 800. Conclusion: Antibodies to P. gingivalis are more common in RA subjects than controls, although lower than that in PD. Associations of P. gingivalis titers with RA-related autoantibody and CRP concentrations suggests that infection with this organism plays a role in disease risk and progression in RA.
AB - Summary: Antibody titers to P. gingivalis are increased in patients with rheumatoid arthritis and are associated with disease-specific autoimmunity. Background: Periodontitis (PD) has been implicated as a risk factor for rheumatoid arthritis (RA). We sought to characterize antibody titers to P. gingivalis (a pathogen in PD) in subjects with RA, PD, and in healthy controls and to examine their relationship with disease autoantibodies. Methods: P. gingivalis antibody was measured in subjects with RA (n = 78), PD (n = 39), and in controls (n = 40). Group frequencies of bacterial titer elevations were compared using the Chi-square test and antibody titers were compared using non-parametric tests. Correlations of P. gingivalis titer with C-reactive protein (CRP), antibody to cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) were examined in those with RA while CRP and autoantibody concentrations were compared based on seropositivity to P. gingivalis. Results: Antibody titers to P. gingivalis were highest in PD, lowest in controls, and intermediate in RA (p = 0.0003). Elevations in P. gingivalis (titer ≥ 800) were more common in RA and PD (67% and 77%, respectively) than in controls (40%) (p = 0.002). In RA, there were significant correlations with P. gingivalis titer with CRP, anti-CCP-IgM, and -IgG-2. CRP (p = 0.006), anti-CCP-IgM (p = 0.01) and -IgG2 (p = 0.04) concentrations were higher in RA cases with P. gingivalis titers ≥ 800 compared to cases with titers < 800. Conclusion: Antibodies to P. gingivalis are more common in RA subjects than controls, although lower than that in PD. Associations of P. gingivalis titers with RA-related autoantibody and CRP concentrations suggests that infection with this organism plays a role in disease risk and progression in RA.
KW - Anti-CCP
KW - Periodontitis
KW - Porphyromonas gingivalis
KW - Rheumatoid arthritis
KW - Rheumatoid factor
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U2 - 10.1016/j.intimp.2008.09.008
DO - 10.1016/j.intimp.2008.09.008
M3 - Article
C2 - 18848647
AN - SCOPUS:58149467119
SN - 1567-5769
VL - 9
SP - 38
EP - 42
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 1
ER -