Anticholinergic poisoning in colicky infants treated with hyoscyamine sulfate

John H. Myers, Donna Moro-Sutherland, Joan E. Shook

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Hyoscyamine, one of the principal alkaloid components of belladonna, is a potent anticholinergic agent. Because of its anticholinergic properties, hyoscyamine sulfate drops are often prescribed for the treatment of colic in infants. Anticholinergic poisoning in infants is rare. However, five cases are reported of infants with anticholinergic toxicity following the administration of hyoscyamine drops for the treatment of colic. Common presenting symptoms included irritability, tachycardia, and erythematous flushed skin. These cases emphasize the need for a heightened awareness by emergency physicians and pediatricians of possible anticholinergic toxicity caused by the use of hyoscyamine for infant colic.

Original languageEnglish (US)
Pages (from-to)532-535
Number of pages4
JournalAmerican Journal of Emergency Medicine
Issue number5
StatePublished - 1997
Externally publishedYes


  • Anticholinergic toxicity
  • Colic
  • Hyoscyamine
  • Infant

ASJC Scopus subject areas

  • Emergency Medicine


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