Abstract
Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.
Original language | English (US) |
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Pages (from-to) | 1556-1559 |
Number of pages | 4 |
Journal | Journal of Rheumatology |
Volume | 46 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1 2019 |
Keywords
- AGE
- ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES
- RHEUMATOID ARTHRITIS
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology