@article{cb6c073a50cf4eda87b3155b379fa2d1,
title = "Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis",
abstract = "Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.",
keywords = "AGE, ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES, RHEUMATOID ARTHRITIS",
author = "Berens, {Heather M.} and Polinski, {Kristen J.} and Mikuls, {Ted R.} and Sonia Khatter and Justin August and Ashley Visser and Michael Mahler and Weisman, {Michael H.} and O'Dell, {James R.} and Keating, {Richard M.} and Buckner, {Jane H.} and Gregersen, {Peter K.} and Norris, {Jill M.} and Holers, {V. Michael} and Deane, {Kevin D.} and Demoruelle, {M. Kristen}",
note = "Funding Information: From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; Division of Rheumatology, University of Nebraska Medical Center, Omaha; Division of Rheumatology, Veterans Affairs (VA) Nebraska Western Iowa Health Care System, Omaha, Nebraska; Department of Research, Inova Diagnostics, San Diego; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles; Division of Rheumatology, Scripps Green Hospital, La Jolla, California; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA. This work was supported by the US National Institutes of Health (NIH; grant numbers AR066712, AI110503, AI101981, and T32AR007534), and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors{\textquoteright} sole responsibility and do not necessarily represent official NIH views. M. Mahler is an employee of Inova Diagnostics. H.M. Berens, MD, PhD, Rheumatology Fellow, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.J. Polinski, BS, PhD student, Department of Epidemiology, Colorado School of Public Health; T.R. Mikuls, MD, MSPH, Professor of Medicine, Division of Rheumatology, University of Nebraska Medical Center, and Division of Rheumatology, VA Nebraska Western Iowa Health Care System; S. Khatter, MD, Resident, Division of Rheumatology, University of Colorado Anschutz Medical Campus; J. August, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; A. Visser, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M. Mahler, PhD, Vice President of Research and Development, Department of Research, Inova Diagnostics; M.H. Weisman, MD, Professor of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center; J.R. O{\textquoteright}Dell, MD, Professor and Vice Chair Internal Medicine, Chief of Rheumatology, Division of Rheumatology, University of Nebraska Medical Center; R.M. Keating, MD, Professor of Medicine, Division of Rheumatology, Scripps Green Hospital; J.H. Buckner, MD, President, Department of Immunology, Benaroya Research Institute at Virginia Mason; P.K. Gregersen, MD, Professor of Molecular Medicine, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research; J.M. Norris, PhD, Professor and Chair of Epidemiology, Department of Epidemiology, Colorado School of Public Health; V.M. Holers, MD, Professor of Medicine, Chair of Rheumatology, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.D. Deane, MD, PhD, Associate Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M.K. Demoruelle, MD, PhD, Assistant Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus. Address correspondence to Dr. M.K. Demoruelle, University of Colorado Denver School of Medicine, Division of Rheumatology, 1775 Aurora Court, Mail Stop B-115, Aurora, Colorado 80045, USA. E-mail: Kristen.Demoruelle@UCDenver.edu Accepted for publication April 1, 2019. Publisher Copyright: {\textcopyright} 2019. All rights reserved.",
year = "2019",
month = dec,
day = "1",
doi = "10.3899/jrheum.180897",
language = "English (US)",
volume = "46",
pages = "1556--1559",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "12",
}