Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis

Heather M. Berens, Kristen J. Polinski, Ted R. Mikuls, Sonia Khatter, Justin August, Ashley Visser, Michael Mahler, Michael H. Weisman, James R. O'Dell, Richard M. Keating, Jane H. Buckner, Peter K. Gregersen, Jill M. Norris, V. Michael Holers, Kevin D. Deane, M. Kristen Demoruelle

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.

Original languageEnglish (US)
Pages (from-to)1556-1559
Number of pages4
JournalJournal of Rheumatology
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2019

Keywords

  • AGE
  • ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES
  • RHEUMATOID ARTHRITIS

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Berens, H. M., Polinski, K. J., Mikuls, T. R., Khatter, S., August, J., Visser, A., Mahler, M., Weisman, M. H., O'Dell, J. R., Keating, R. M., Buckner, J. H., Gregersen, P. K., Norris, J. M., Holers, V. M., Deane, K. D., & Demoruelle, M. K. (2019). Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis. Journal of Rheumatology, 46(12), 1556-1559. https://doi.org/10.3899/jrheum.180897