Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis

Heather M. Berens; Kristen J. Polinski; Ted R. Mikuls; Sonia Khatter; Justin August; Ashley Visser; Michael Mahler; Michael H. Weisman; James R. O'Dell; Richard M. Keating; Jane H. Buckner; Peter K. Gregersen; Jill M. Norris; V. Michael Holers; Kevin D. Deane; M. Kristen Demoruelle

doi:10.3899/jrheum.180897

Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis

Heather M. Berens, Kristen J. Polinski, Ted R. Mikuls, Sonia Khatter, Justin August, Ashley Visser, Michael Mahler, Michael H. Weisman, James R. O'Dell, Richard M. Keating, Jane H. Buckner, Peter K. Gregersen, Jill M. Norris, V. Michael Holers, Kevin D. Deane, M. Kristen Demoruelle

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.

Original language	English (US)
Pages (from-to)	1556-1559
Number of pages	4
Journal	Journal of Rheumatology
Volume	46
Issue number	12
DOIs	https://doi.org/10.3899/jrheum.180897
State	Published - Dec 1 2019

Keywords

AGE
ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES
RHEUMATOID ARTHRITIS

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Access to Document

10.3899/jrheum.180897

Cite this

Berens, H. M., Polinski, K. J., Mikuls, T. R., Khatter, S., August, J., Visser, A., Mahler, M., Weisman, M. H., O'Dell, J. R., Keating, R. M., Buckner, J. H., Gregersen, P. K., Norris, J. M., Holers, V. M., Deane, K. D., & Demoruelle, M. K. (2019). Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis. Journal of Rheumatology, 46(12), 1556-1559. https://doi.org/10.3899/jrheum.180897

Berens, HM, Polinski, KJ, Mikuls, TR, Khatter, S, August, J, Visser, A, Mahler, M, Weisman, MH, O'Dell, JR, Keating, RM, Buckner, JH, Gregersen, PK, Norris, JM, Holers, VM, Deane, KD & Demoruelle, MK 2019, 'Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis', Journal of Rheumatology, vol. 46, no. 12, pp. 1556-1559. https://doi.org/10.3899/jrheum.180897

@article{cb6c073a50cf4eda87b3155b379fa2d1,

title = "Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis",

abstract = "Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.",

keywords = "AGE, ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES, RHEUMATOID ARTHRITIS",

author = "Berens, {Heather M.} and Polinski, {Kristen J.} and Mikuls, {Ted R.} and Sonia Khatter and Justin August and Ashley Visser and Michael Mahler and Weisman, {Michael H.} and O'Dell, {James R.} and Keating, {Richard M.} and Buckner, {Jane H.} and Gregersen, {Peter K.} and Norris, {Jill M.} and Holers, {V. Michael} and Deane, {Kevin D.} and Demoruelle, {M. Kristen}",

year = "2019",

month = dec,

day = "1",

doi = "10.3899/jrheum.180897",

language = "English (US)",

volume = "46",

pages = "1556--1559",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "12",

}

TY - JOUR

T1 - Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis

AU - Berens, Heather M.

AU - Polinski, Kristen J.

AU - Mikuls, Ted R.

AU - Khatter, Sonia

AU - August, Justin

AU - Visser, Ashley

AU - Mahler, Michael

AU - Weisman, Michael H.

AU - O'Dell, James R.

AU - Keating, Richard M.

AU - Buckner, Jane H.

AU - Gregersen, Peter K.

AU - Norris, Jill M.

AU - Holers, V. Michael

AU - Deane, Kevin D.

AU - Demoruelle, M. Kristen

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.

AB - Objective. We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). Methods. Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. Results. In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. Conclusion. Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.

KW - AGE

KW - ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODIES

KW - RHEUMATOID ARTHRITIS

UR - http://www.scopus.com/inward/record.url?scp=85075957626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075957626&partnerID=8YFLogxK

U2 - 10.3899/jrheum.180897

DO - 10.3899/jrheum.180897

M3 - Article

C2 - 30988128

AN - SCOPUS:85075957626

SN - 0315-162X

VL - 46

SP - 1556

EP - 1559

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 12

ER -

Anticyclic citrullinated peptide antibodies 3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this