Antidiarrhoeal effects of methanolic root extract of Hemidesmus indicus (Indian sarsaparilla) - An in vitro and in vivo study

Sarita Das, R. Prakash, S. Niranjali Devaraj

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Methanolic extract of H. indicus root (MHI) was screened for its antimicrobial activity against S. typhimurium, E. coli and S. flexneri, in vitro and in experimentally induced diarrhoea in albino rats, in vivo. MHI had an anti enterobacteriae effect as evident from agar well diffusion method and decrease in CFU/ml in MHI treated LB broth culture. MHI inhibited the castor oil induced diarrhoea in rats as judged by a decrease in the amount of wet faeces in MHI-pretreated rats at a dose of 500-1500 mg/kg. The results indicated that MHI was more active than standard antidiarrhoeal drug, lomotil. Phytochemical tests revealed the main constituents as tannins, steroids, triterpenoids and carbohydrates. Present findings suggested that MHI might elicit an antidiarrhoeal effect by inhibition of intestinal motility and by its bacteriocidal activity.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalIndian journal of experimental biology
Volume41
Issue number4
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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