Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

Rebecca J. Garten; C. Todd Davis; Colin A. Russell; Bo Shu; Stephen Lindstrom; Amanda Balish; Wendy M. Sessions; Xiyan Xu; Eugene Skepner; Varough Deyde; Margaret Okomo-Adhiambo; Larisa Gubareva; John Barnes; Catherine B. Smith; Shannon L. Emery; Michael J. Hillman; Pierre Rivailler; James Smagala; Miranda De Graaf; David F. Burke; Ron A M Fouchier; Claudia Pappas; Celia M. Alpuche-Aranda; Hugo López-Gatell; Hiram Olivera; Irma López; Christopher A. Myers; Dennis Faix; Patrick J. Blair; Cindy Yu; Kimberly M. Keene; P. David Dotson; David Boxrud; Anthony R. Sambol; Syed H. Abid; Kirsten St. George; Tammy Bannerman; Amanda L. Moore; David J. Stringer; Patricia Blevins; Gail J. Demmler-Harrison; Michele Ginsberg; Paula Kriner; Steve Waterman; Sandra Smole; Hugo F. Guevara; Edward A. Belongia; Patricia A. Clark; Sara T. Beatrice; Ruben Donis; Jacqueline Katz; Lyn Finelli; Carolyn B. Bridges; Michael Shaw; Daniel B. Jernigan; Timothy M. Uyeki; Derek J. Smith; Alexander I. Klimov; Nancy J. Cox

doi:10.1126/science.1176225

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

Rebecca J. Garten, C. Todd Davis, Colin A. Russell, Bo Shu, Stephen Lindstrom, Amanda Balish, Wendy M. Sessions, Xiyan Xu, Eugene Skepner, Varough Deyde, Margaret Okomo-Adhiambo, Larisa Gubareva, John Barnes, Catherine B. Smith, Shannon L. Emery, Michael J. Hillman, Pierre Rivailler, James Smagala, Miranda De Graaf, David F. BurkeRon A M Fouchier, Claudia Pappas, Celia M. Alpuche-Aranda, Hugo López-Gatell, Hiram Olivera, Irma López, Christopher A. Myers, Dennis Faix, Patrick J. Blair, Cindy Yu, Kimberly M. Keene, P. David Dotson, David Boxrud, Anthony R. Sambol, Syed H. Abid, Kirsten St. George, Tammy Bannerman, Amanda L. Moore, David J. Stringer, Patricia Blevins, Gail J. Demmler-Harrison, Michele Ginsberg, Paula Kriner, Steve Waterman, Sandra Smole, Hugo F. Guevara, Edward A. Belongia, Patricia A. Clark, Sara T. Beatrice, Ruben Donis, Jacqueline Katz, Lyn Finelli, Carolyn B. Bridges, Michael Shaw, Daniel B. Jernigan, Timothy M. Uyeki, Derek J. Smith, Alexander I. Klimov, Nancy J. Cox

Research output: Contribution to journal › Article › peer-review

2160 Scopus citations

Abstract

Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

Original language	English (US)
Pages (from-to)	197-201
Number of pages	5
Journal	Science
Volume	325
Issue number	5937
DOIs	https://doi.org/10.1126/science.1176225
State	Published - Jul 10 2009

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1176225

Cite this

Garten, R. J., Davis, C. T., Russell, C. A., Shu, B., Lindstrom, S., Balish, A., Sessions, W. M., Xu, X., Skepner, E., Deyde, V., Okomo-Adhiambo, M., Gubareva, L., Barnes, J., Smith, C. B., Emery, S. L., Hillman, M. J., Rivailler, P., Smagala, J., De Graaf, M., ... Cox, N. J. (2009). Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science, 325(5937), 197-201. https://doi.org/10.1126/science.1176225

Garten, RJ, Davis, CT, Russell, CA, Shu, B, Lindstrom, S, Balish, A, Sessions, WM, Xu, X, Skepner, E, Deyde, V, Okomo-Adhiambo, M, Gubareva, L, Barnes, J, Smith, CB, Emery, SL, Hillman, MJ, Rivailler, P, Smagala, J, De Graaf, M, Burke, DF, Fouchier, RAM, Pappas, C, Alpuche-Aranda, CM, López-Gatell, H, Olivera, H, López, I, Myers, CA, Faix, D, Blair, PJ, Yu, C, Keene, KM, Dotson, PD, Boxrud, D, Sambol, AR, Abid, SH, St. George, K, Bannerman, T, Moore, AL, Stringer, DJ, Blevins, P, Demmler-Harrison, GJ, Ginsberg, M, Kriner, P, Waterman, S, Smole, S, Guevara, HF, Belongia, EA, Clark, PA, Beatrice, ST, Donis, R, Katz, J, Finelli, L, Bridges, CB, Shaw, M, Jernigan, DB, Uyeki, TM, Smith, DJ, Klimov, AI & Cox, NJ 2009, 'Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans', Science, vol. 325, no. 5937, pp. 197-201. https://doi.org/10.1126/science.1176225

@article{bc1ec78749f349998544a190ae3781c3,

title = "Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans",

abstract = "Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).",

author = "Garten, {Rebecca J.} and Davis, {C. Todd} and Russell, {Colin A.} and Bo Shu and Stephen Lindstrom and Amanda Balish and Sessions, {Wendy M.} and Xiyan Xu and Eugene Skepner and Varough Deyde and Margaret Okomo-Adhiambo and Larisa Gubareva and John Barnes and Smith, {Catherine B.} and Emery, {Shannon L.} and Hillman, {Michael J.} and Pierre Rivailler and James Smagala and {De Graaf}, Miranda and Burke, {David F.} and Fouchier, {Ron A M} and Claudia Pappas and Alpuche-Aranda, {Celia M.} and Hugo L{\'o}pez-Gatell and Hiram Olivera and Irma L{\'o}pez and Myers, {Christopher A.} and Dennis Faix and Blair, {Patrick J.} and Cindy Yu and Keene, {Kimberly M.} and Dotson, {P. David} and David Boxrud and Sambol, {Anthony R.} and Abid, {Syed H.} and {St. George}, Kirsten and Tammy Bannerman and Moore, {Amanda L.} and Stringer, {David J.} and Patricia Blevins and Demmler-Harrison, {Gail J.} and Michele Ginsberg and Paula Kriner and Steve Waterman and Sandra Smole and Guevara, {Hugo F.} and Belongia, {Edward A.} and Clark, {Patricia A.} and Beatrice, {Sara T.} and Ruben Donis and Jacqueline Katz and Lyn Finelli and Bridges, {Carolyn B.} and Michael Shaw and Jernigan, {Daniel B.} and Uyeki, {Timothy M.} and Smith, {Derek J.} and Klimov, {Alexander I.} and Cox, {Nancy J.}",

year = "2009",

month = jul,

day = "10",

doi = "10.1126/science.1176225",

language = "English (US)",

volume = "325",

pages = "197--201",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5937",

}

TY - JOUR

T1 - Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

AU - Garten, Rebecca J.

AU - Davis, C. Todd

AU - Russell, Colin A.

AU - Shu, Bo

AU - Lindstrom, Stephen

AU - Balish, Amanda

AU - Sessions, Wendy M.

AU - Xu, Xiyan

AU - Skepner, Eugene

AU - Deyde, Varough

AU - Okomo-Adhiambo, Margaret

AU - Gubareva, Larisa

AU - Barnes, John

AU - Smith, Catherine B.

AU - Emery, Shannon L.

AU - Hillman, Michael J.

AU - Rivailler, Pierre

AU - Smagala, James

AU - De Graaf, Miranda

AU - Burke, David F.

AU - Fouchier, Ron A M

AU - Pappas, Claudia

AU - Alpuche-Aranda, Celia M.

AU - López-Gatell, Hugo

AU - Olivera, Hiram

AU - López, Irma

AU - Myers, Christopher A.

AU - Faix, Dennis

AU - Blair, Patrick J.

AU - Yu, Cindy

AU - Keene, Kimberly M.

AU - Dotson, P. David

AU - Boxrud, David

AU - Sambol, Anthony R.

AU - Abid, Syed H.

AU - St. George, Kirsten

AU - Bannerman, Tammy

AU - Moore, Amanda L.

AU - Stringer, David J.

AU - Blevins, Patricia

AU - Demmler-Harrison, Gail J.

AU - Ginsberg, Michele

AU - Kriner, Paula

AU - Waterman, Steve

AU - Smole, Sandra

AU - Guevara, Hugo F.

AU - Belongia, Edward A.

AU - Clark, Patricia A.

AU - Beatrice, Sara T.

AU - Donis, Ruben

AU - Katz, Jacqueline

AU - Finelli, Lyn

AU - Bridges, Carolyn B.

AU - Shaw, Michael

AU - Jernigan, Daniel B.

AU - Uyeki, Timothy M.

AU - Smith, Derek J.

AU - Klimov, Alexander I.

AU - Cox, Nancy J.

PY - 2009/7/10

Y1 - 2009/7/10

N2 - Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

AB - Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

UR - http://www.scopus.com/inward/record.url?scp=67650407532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650407532&partnerID=8YFLogxK

U2 - 10.1126/science.1176225

DO - 10.1126/science.1176225

M3 - Article

C2 - 19465683

AN - SCOPUS:67650407532

SN - 0036-8075

VL - 325

SP - 197

EP - 201

JO - Science

JF - Science

IS - 5937

ER -

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this