Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats

R. Baskar, L. Md Bhakshu, G. Vijaya Bharathi, S. Sreenivasa Reddy, R. Karuna, G. Kesava Reddy, D. Saralakumari

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The aim of the current study was to examine the antidiabetic action of Rubia cordifolia Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg-1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.

Original languageEnglish (US)
Pages (from-to)475-479
Number of pages5
JournalPharmaceutical Biology
Volume44
Issue number6
DOIs
StatePublished - Aug 1 2006

Keywords

  • Antidiabetic
  • Diabetes
  • Rubia cordifolia
  • Transaminases

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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