Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats

R. Baskar; L. Md Bhakshu; G. Vijaya Bharathi; S. Sreenivasa Reddy; R. Karuna; G. Kesava Reddy; D. Saralakumari

doi:10.1080/13880200600798593

Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats

R. Baskar, L. Md Bhakshu, G. Vijaya Bharathi, S. Sreenivasa Reddy, R. Karuna, G. Kesava Reddy, D. Saralakumari

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The aim of the current study was to examine the antidiabetic action of Rubia cordifolia Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg^-1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.

Original language	English (US)
Pages (from-to)	475-479
Number of pages	5
Journal	Pharmaceutical Biology
Volume	44
Issue number	6
DOIs	https://doi.org/10.1080/13880200600798593
State	Published - Aug 1 2006
Externally published	Yes

Keywords

Antidiabetic
Diabetes
Rubia cordifolia
Transaminases

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1080/13880200600798593

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title = "Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats",

abstract = "The aim of the current study was to examine the antidiabetic action of Rubia cordifolia Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg-1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.",

keywords = "Antidiabetic, Diabetes, Rubia cordifolia, Transaminases",

author = "R. Baskar and Bhakshu, {L. Md} and Bharathi, {G. Vijaya} and Reddy, {S. Sreenivasa} and R. Karuna and Reddy, {G. Kesava} and D. Saralakumari",

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AU - Baskar, R.

AU - Bhakshu, L. Md

AU - Bharathi, G. Vijaya

AU - Reddy, S. Sreenivasa

AU - Karuna, R.

AU - Reddy, G. Kesava

AU - Saralakumari, D.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - The aim of the current study was to examine the antidiabetic action of Rubia cordifolia Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg-1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.

AB - The aim of the current study was to examine the antidiabetic action of Rubia cordifolia Linn (Rubiaceae) aqueous root extract (RCAREt) in streptozotocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were treated with RCAREt for 8 weeks (1 g kg-1 b.w., orally per day). Serum glucose, total cholesterol and triglycerides, hematological parameters, and liver and kidney transaminases in normal, STZ diabetic, and RCAREt-treated diabetic rats were measured. The observed hyperglycemia, hypertriglyceridemia, enhanced transaminases of liver and kidney, hypochromic microcytic anemia, and loss of body weight in STZ diabetic rats were normalized by RCAREt treatment, whereas the hypercholesterolemia was not rectified. The beneficial effect of RCAREt treatment might be due to different types of active principles, each with a single or a diverse range of biological activities.

KW - Antidiabetic

KW - Diabetes

KW - Rubia cordifolia

KW - Transaminases

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Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats

Abstract

Keywords

ASJC Scopus subject areas

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