Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid

Keith M. Olsen; Tom E. Peddicord; G. Douglas Campbell; Mark E. Rupp

doi:10.1093/jac/45.2.217

Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid

Keith M. Olsen, Tom E. Peddicord, G. Douglas Campbell, Mark E. Rupp

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BAL(f) containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 10⁵ cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.

Original language	English (US)
Pages (from-to)	217-219
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	45
Issue number	2
DOIs	https://doi.org/10.1093/jac/45.2.217
State	Published - 2000

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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title = "Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid",

abstract = "The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BAL(f) containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 105 cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.",

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AU - Olsen, Keith M.

AU - Peddicord, Tom E.

AU - Campbell, G. Douglas

AU - Rupp, Mark E.

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AB - The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BAL(f) containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 105 cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.

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