Antineoplastic actions of cinnamic acids and their dimers in breast cancer cells: A comparative study

Megan Hunke, Wuilian Martinez, Akshay Kashyap, Treyvon Bokoskie, Mahesh Pattabiraman, Surabhi Chandra

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background/Aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. The aim of the study was to determine if certain cinnamic acid dimers (CADs) exhibit higher cytotoxicity in breast cancer cells than against nontumorigenic cells. Materials and Methods: These dimers have not been explored, so far, due to their complex stereochemistry; cavitand-mediated photodimerization (CMP) method was used to produce several CADs, which were tested for cytotoxicity, apoptosis and cell cycle inhibition. Results: CADs such as ferulic acid dimer, 3-fluoro CAD, and 3, 4-difluoro CAD, were found to be more cytotoxic than their parent monomers. The most potent compound, 3-fluoro CAD caused apoptosis and 'S' phase cell cycle arrest in cancer cells. Conclusion: This study indicates an avenue for research for developing a novel class of antineoplastic compounds that can be synthesized using an easy, economical method.

Original languageEnglish (US)
Pages (from-to)4469-4474
Number of pages6
JournalAnticancer Research
Volume38
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • Apoptosis
  • Breast cancer cells
  • Cell cycle arrest
  • Cinnamic acid dimer
  • Photodimerization

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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