Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 141

George R. Pettit, Yoshiaki Kamano, Cherry L. Herald, Claude Dufresne, Jean M. Schmidt, Robert B. Bates, Ronald L. Cerny, Haruhisa Kizu

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

: The Indian Ocean sea hare Dolabella auricularia has been found to contain a novel cytostatic (PS ED50 0.022 µg/mL) cyclodepsipeptide designated dolastatin 14. Structure 1 was assigned dolastatin 14 and was deduced primarily by a series of 2D NMR studies at high field (400 MHz).

Original languageEnglish (US)
Pages (from-to)2989-2990
Number of pages2
JournalJournal of Organic Chemistry
Volume55
Issue number10
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Organic Chemistry

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    Pettit, G. R., Kamano, Y., Herald, C. L., Dufresne, C., Schmidt, J. M., Bates, R. B., Cerny, R. L., & Kizu, H. (1990). Antineoplastic Agents. 190. Isolation and Structure of the Cyclodepsipeptide Dolastatin 141. Journal of Organic Chemistry, 55(10), 2989-2990. https://doi.org/10.1021/jo00297a001