Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5

George R. Pettit, Jun ping Xu, Zbigniew A. Cichacz, Michael D. Williams, Ann Christine Dorsaz, Daniel C. Brune, Michael R. Boyd, Ronald L. Cerny

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10-6 % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25°C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.

Original languageEnglish (US)
Pages (from-to)2091-2096
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number17
DOIs
StatePublished - Sep 8 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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