TY - JOUR
T1 - Antineoplastic agents 323. Isolation and structure of phakellistatin 6 from a Chuuk archipelago marine sponge
AU - Pettit, George R.
AU - Xu, Jun Ping
AU - Cichacz, Zbigniew A.
AU - Williams, Michael D.
AU - Chapuis, Jean Charles
AU - Cerny, Ronald L.
PY - 1994/11
Y1 - 1994/11
N2 - Phakellistatin 6 (7), a trace (7.5 × 10-7% yield) constituent of the marine sponge Phakellia costata located in the Federated States of Micronesia has been found to significantly inhibit growth of certain human cancer cell lines (GI50, 0.1 to 0.01 μg/ml). The structure of phakellistatin 6 (7) was deduced as cyclo (Pro-Trp-Leu-Pro-Ile-Pro-Phe) employing a combination of MS/MS and high field (500 MHz) 2D-NMR procedures followed by chiral (all S amino acids) assignments using hydrolysis → derivatisation → chiral chromatographic techniques.
AB - Phakellistatin 6 (7), a trace (7.5 × 10-7% yield) constituent of the marine sponge Phakellia costata located in the Federated States of Micronesia has been found to significantly inhibit growth of certain human cancer cell lines (GI50, 0.1 to 0.01 μg/ml). The structure of phakellistatin 6 (7) was deduced as cyclo (Pro-Trp-Leu-Pro-Ile-Pro-Phe) employing a combination of MS/MS and high field (500 MHz) 2D-NMR procedures followed by chiral (all S amino acids) assignments using hydrolysis → derivatisation → chiral chromatographic techniques.
UR - http://www.scopus.com/inward/record.url?scp=0027985318&partnerID=8YFLogxK
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U2 - 10.1016/S0960-894X(01)80695-8
DO - 10.1016/S0960-894X(01)80695-8
M3 - Article
AN - SCOPUS:0027985318
SN - 0960-894X
VL - 4
SP - 2677
EP - 2682
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 22
ER -