Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

George R. Pettit, Rui Tan, Yoshitatsu Ichihara, Michael D. Williams, Dennis L. Doubek, Larry P. Tackett, Jean M. Schmidt, Ronald L. Cerny, Michael R. Boyd, John N.A. Hooper

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalJournal of Natural Products
Volume58
Issue number6
DOIs
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G. R., Tan, R., Ichihara, Y., Williams, M. D., Doubek, D. L., Tackett, L. P., Schmidt, J. M., Cerny, R. L., Boyd, M. R., & Hooper, J. N. A. (1995). Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp. Journal of Natural Products, 58(6), 961-965. https://doi.org/10.1021/np50120a025