Antineoplastic agents 370. Isolation and structure of dolastatin 18

George R. Pettit, Jun Ping Xu, Michael D. Williams, Fiona Hogan, Jean M. Schmidt, Ronald L. Cerny

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Bioassay-guided separation of cancer cell growth inhibitory fractions derived from the sea hare Dolabella auricularia obtained in Papua New Guinea led to isolation (1.51 x 10-7 % yield) of the new thiazole-containing peptide, dolastatin 18 (4). Structural determination was completed by employment of results from high-field (500 MHz) 2-D NMR experiments and tandem MS/MS mass spectral sequence analyses. Dolastatin 18 (4) was found to inhibit a selection of cancer cell lines among which GI50 0.39 μg/mL was found for the non-small cell lung cancer NCI-H460.

Original languageEnglish (US)
Pages (from-to)827-832
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number7
DOIs
StatePublished - Apr 8 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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