Antioxidant gene therapy against neuronal cell death

Juliana Navarro-Yepes, Laura Zavala-Flores, Annadurai Anandhan, Fang Wang, Maciej Skotak, Namas Chandra, Ming Li, Aglaia Pappa, Daniel Martinez-Fong, Luz Maria Del Razo, Betzabet Quintanilla-Vega, Rodrigo Franco

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy.

Original languageEnglish (US)
Pages (from-to)206-230
Number of pages25
JournalPharmacology and Therapeutics
Volume142
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • Antioxidant gene therapy
  • Brain ischemia
  • Neurodegenerative disorders
  • Oxidative stress
  • ROS
  • Virus-mediated gene delivery

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Navarro-Yepes, J., Zavala-Flores, L., Anandhan, A., Wang, F., Skotak, M., Chandra, N., Li, M., Pappa, A., Martinez-Fong, D., Del Razo, L. M., Quintanilla-Vega, B., & Franco, R. (2014). Antioxidant gene therapy against neuronal cell death. Pharmacology and Therapeutics, 142(2), 206-230. https://doi.org/10.1016/j.pharmthera.2013.12.007