Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection

Jeffrey A. Lieberman, Frank P. Bymaster, Herbert Y. Meltzer, Ariel Y. Deutch, Gary E. Duncan, Christine E. Marx, June R. Aprille, Donard S. Dwyer, Xin Min Li, Sahebarao P. Mahadik, Ronald S. Duman, Joseph H. Porter, Josephine S. Modica-Napolitano, Samuel S. Newton, John G. Csernansky

Research output: Contribution to journalReview articlepeer-review

187 Scopus citations


Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, antipsychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article reviews the current literature describing preclinical and clinical studies that evaluate the efficacy of antipsychotic drugs, their mechanism of action and the potential of first- and second-generation antipsychotic drugs to exert effects on cellular processes that may be neuroprotective in schizophrenia. The evidence to date suggests that although all antipsychotic drugs have the ability to reduce psychotic symptoms via D2 receptor antagonism, some antipsychotics may differ in other pharmacological properties and their capacities to mitigate and possibly reverse cellular processes that may underlie the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)358-403
Number of pages46
JournalPharmacological Reviews
Issue number3
StatePublished - Sep 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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