Antiretrovirals for Human Immunodeficiency Virus Treatment and Prevention in Pregnancy

Kristina M. Brooks, Kimberly K. Scarsi, Mark Mirochnick

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Safe and effective antiretroviral medications are needed during pregnancy to reduce maternal morbidity and mortality associated with untreated human immunodeficiency virus (HIV) infection and to prevent viral transmission to the infant. Pharmacokinetic studies have helped inform the appropriate dosing of antiretroviral medications during pregnancy. However, data from these studies consistently become available years after initial regulatory approvals in nonpregnant adults. In this article, the authors provide an overview of considerations in use of antiretroviral medications in pregnant people with or at risk for HIV, pharmacokinetic studies that helped support recommended options, and therapies either under active investigation or in need of prospective study.

Original languageEnglish (US)
Pages (from-to)205-218
Number of pages14
JournalObstetrics and Gynecology Clinics of North America
Volume50
Issue number1
DOIs
StatePublished - Mar 2023

Keywords

  • Antiretroviral therapy
  • HIV
  • Obstetric care
  • Pharmacokinetics
  • Preexposure prophylaxis
  • Pregnant

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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