Antisense DNA and RNA agents against picornaviruses

Travis Lim, Jane Yuan, Huifang Mary Zhang, Alhousseynou Sall, Zhen Liu, Yue Su, Decheng Yang

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Anti-picornaviral antisense agents are part of a broader group of nucleic acid-based molecules developed for sequence-specific inhibition of translation and/or transcription of the target sequence through induced nuclease activity or physical hindrance. Three types of nucleic acid-based gene silencing molecules can be distinguished, including DNA-base antisense oligonucleotides (ASO), nucleic acid enzymes (ribozyme and DNAzyme) and double-stranded small interfering RNA (siRNA or microRNA). These antisense DNA and RNA molecules have been widely studied for gene functional studies and therapeutic purposes. In this review, we focus on drug development using ASO and siRNA strategies to inhibit picornavirus infections. The picornavirus genome organization and life cycle is described, followed by discussion of design considerations, chemical modifications and drug delivery approaches. Recent studies using antisense against picornavirus are reviewed. Finally, we compare the advantages and disadvantages of the antisense agents with those of other therapeutics, taking into consideration their limitations which need to be overcome to achieve the final goal of clinical application.

Original languageEnglish (US)
Pages (from-to)4707-4725
Number of pages19
JournalFrontiers in Bioscience
Volume13
Issue number12
DOIs
StatePublished - 2008

Keywords

  • Antisense
  • Antisense oligonucleotides
  • Antiviral drag therapy
  • Coxsackievirus B3
  • Enterovirus
  • Phosphorodiamidate morpholino oligomer
  • Picornavirus
  • Review
  • Small interfering RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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