TY - JOUR
T1 - Antisense DNA and RNA
T2 - Potential therapeutics for viral infection
AU - Yuan, Ji
AU - Lim, Travis
AU - Liu, Zhen
AU - Qiu, Dexin
AU - Wong, Brian
AU - Luo, Honglin
AU - Si, Xiaoning
AU - McManus, Bruce
AU - Yang, Decheng
PY - 2006/10
Y1 - 2006/10
N2 - Antisense DNA and RNA are valuable tools to inhibit expression of a target gene in a sequence-specific manner. These molecules are not only widely used for gene functional study but also for therapeutic purpose. The strategy for therapeutics is attributed to its specific inhibition of gene expression of pathogens or disease-causing genes. Three types of anti-mRNA strategies can be distinguished, including antisense oligodeoxynucleotide (AODN), nucleic acid enzymes, and double-stranded small interfering RNA (siRNA). In this article we overview the basic principles of AODN and siRNA and then focus on their potential applications in antiviral therapy including our own data on coxsackieviral infection, a common pathogen of human myocarditis. In addition, we also briefly discuss the problems and difficulties in these drug developments, which need to be overcome to achieve the final goal in clinical application.
AB - Antisense DNA and RNA are valuable tools to inhibit expression of a target gene in a sequence-specific manner. These molecules are not only widely used for gene functional study but also for therapeutic purpose. The strategy for therapeutics is attributed to its specific inhibition of gene expression of pathogens or disease-causing genes. Three types of anti-mRNA strategies can be distinguished, including antisense oligodeoxynucleotide (AODN), nucleic acid enzymes, and double-stranded small interfering RNA (siRNA). In this article we overview the basic principles of AODN and siRNA and then focus on their potential applications in antiviral therapy including our own data on coxsackieviral infection, a common pathogen of human myocarditis. In addition, we also briefly discuss the problems and difficulties in these drug developments, which need to be overcome to achieve the final goal in clinical application.
KW - Antisense
KW - Antiviral agents
KW - Coxsackievirus B3
KW - Oligodeoxynucleotide
KW - Small interfering RNA
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U2 - 10.2174/187152106778520460
DO - 10.2174/187152106778520460
M3 - Review article
AN - SCOPUS:33750091940
SN - 1871-5214
VL - 5
SP - 367
EP - 377
JO - Anti-Infective Agents in Medicinal Chemistry
JF - Anti-Infective Agents in Medicinal Chemistry
IS - 4
ER -