Antisense DNA and RNA: Potential therapeutics for viral infection

Ji Yuan, Travis Lim, Zhen Liu, Dexin Qiu, Brian Wong, Honglin Luo, Xiaoning Si, Bruce McManus, Decheng Yang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Antisense DNA and RNA are valuable tools to inhibit expression of a target gene in a sequence-specific manner. These molecules are not only widely used for gene functional study but also for therapeutic purpose. The strategy for therapeutics is attributed to its specific inhibition of gene expression of pathogens or disease-causing genes. Three types of anti-mRNA strategies can be distinguished, including antisense oligodeoxynucleotide (AODN), nucleic acid enzymes, and double-stranded small interfering RNA (siRNA). In this article we overview the basic principles of AODN and siRNA and then focus on their potential applications in antiviral therapy including our own data on coxsackieviral infection, a common pathogen of human myocarditis. In addition, we also briefly discuss the problems and difficulties in these drug developments, which need to be overcome to achieve the final goal in clinical application.

Original languageEnglish (US)
Pages (from-to)367-377
Number of pages11
JournalAnti-Infective Agents in Medicinal Chemistry
Volume5
Issue number4
DOIs
StatePublished - Oct 2006

Keywords

  • Antisense
  • Antiviral agents
  • Coxsackievirus B3
  • Oligodeoxynucleotide
  • Small interfering RNA

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases

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