Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation

Sajeev Balakrishnan, Christopher Colling, Tab Burkman, Judi Erickson, Elizabeth Lyden, Hiralal Maheshwari, Lynn Mack-Shipman, James Lane, Jennifer Larsen

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13 Scopus citations

Abstract

Background. Pancreas transplantation (PTX) improves lipids in patients with type 1 diabetes mellitus. However, there are patients who have persistent abnormal lipids or develop new hyperlipidemia despite PTX. One factor that may influence the lipid profile is apolipoprotein E (Apo E) genotype. Apo E polymorphism, particularly E2 and E4 alleles, increases the risk of dyslipidemia. Apo E2 has also been found to increase risk of diabetic nephropathy and so may be more prevalent in PTX candidates. Methods. This study evaluated fasting-lipid profiles in type I 1 diabetes patients who were pancreas transplant candidates to prospectively evaluate the impact of Apo E genotype on dyslipidemia before and after PTX. Results. Presence of one or more E4 alleles resulted in higher triglycerides (P=0.0446), lower HDL (P=0.0247), and a higher cholesterol-to-HDL (C/H) ratio (P=0.0405) before PTX when compared with those with E3/3 genotype. After PTX, lipids improved so there was no longer a difference in fasting lipids between patients with an E4 allele and E3/3 genotype. Presence of an E2 allele had no significant impact on fasting lipids before or after PTX. Conclusions. Presence of an Apo E4 allele worsened HDL, triglycerides, and C/H ratio before PTX compared with those with E3/3 genotype, whereas the presence of an Apo E2 allele had no significant effect on lipids before or after PTX. Thus, Apo E4 has a larger impact than Apo E2 on fasting-lipid profile in PTX candidates, and Apo E gene polymorphism does not worsen lipid dyslipidemia after PTX, despite introduction of immunosuppressant medications known to cause dyslipidemia.

Original languageEnglish (US)
Pages (from-to)974-977
Number of pages4
JournalTransplantation
Volume74
Issue number7
DOIs
StatePublished - Oct 15 2002

ASJC Scopus subject areas

  • Transplantation

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    Balakrishnan, S., Colling, C., Burkman, T., Erickson, J., Lyden, E., Maheshwari, H., Mack-Shipman, L., Lane, J., & Larsen, J. (2002). Apolipoprotein E gene polymorphism alters lipids before pancreas transplantation. Transplantation, 74(7), 974-977. https://doi.org/10.1097/00007890-200210150-00013